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2001 1
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27 results

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Page 1
Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair.
Gupta N, Matsumoto T, Hiratsuka K, Garcia Saiz E, Galichon P, Miyoshi T, Susa K, Tatsumoto N, Yamashita M, Morizane R. Gupta N, et al. Sci Transl Med. 2022 Mar 2;14(634):eabj4772. doi: 10.1126/scitranslmed.abj4772. Epub 2022 Mar 2. Sci Transl Med. 2022. PMID: 35235339 Free PMC article.
Loss of nephrons correlates with reduced kidney function, which defines chronic kidney disease (CKD) and confers substantial morbidity and mortality to the worldwide population. ...Kidney biopsy samples with tubular injury and varying degrees of fibrosis confirmed loss of …
Loss of nephrons correlates with reduced kidney function, which defines chronic kidney disease (CKD) and confers substantial morbidit …
Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks.
Clay DE, Jezuit EA, Montague RA, Fox DT. Clay DE, et al. G3 (Bethesda). 2022 Jul 29;12(8):jkac129. doi: 10.1093/g3journal/jkac129. G3 (Bethesda). 2022. PMID: 35595243 Free PMC article.
Fanconi anemia genes play key roles in metazoan DNA damage responses, and human FA mutations cause numerous disease phenotypes. In human cells, activating monoubiquitination of the Fanconi anemia protein Fancd2 occurs following diverse DNA damage stimuli. Monoubiqui …
Fanconi anemia genes play key roles in metazoan DNA damage responses, and human FA mutations cause numerous disease phenotypes. In hu …
A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.
Dubois EL, Guitton-Sert L, Béliveau M, Parmar K, Chagraoui J, Vignard J, Pauty J, Caron MC, Coulombe Y, Buisson R, Jacquet K, Gamblin C, Gao Y, Laprise P, Lebel M, Sauvageau G, D d'Andrea A, Masson JY. Dubois EL, et al. Nucleic Acids Res. 2019 Aug 22;47(14):7532-7547. doi: 10.1093/nar/gkz514. Nucleic Acids Res. 2019. PMID: 31219578 Free PMC article.
A critical step in the activation of FA pathway is the monoubiquitination of FANCD2 and its binding partner FANCI. To better address the clinical phenotype associated with FANCI and the epistatic relationship with FANCD2, we created the first conditional inactivatio …
A critical step in the activation of FA pathway is the monoubiquitination of FANCD2 and its binding partner FANCI. To better address …
Fanconi Anemia Mouse Genotype-specific Mitigation of Total Body Irradiation by GS-Nitroxide JP4-039.
Epperly MW, Fisher R, Zhang X, Hou W, Shields D, Wipf P, Wang H, Thermozier S, Greenberger JS. Epperly MW, et al. In Vivo. 2020 Jan-Feb;34(1):33-38. doi: 10.21873/invivo.11742. In Vivo. 2020. PMID: 31882460 Free PMC article.
BACKGROUND/AIM: Radiation mitigator, GS-nitroxide, JP4-039, was evaluated for mitigation of total body irradiation (TBI) in Fanconi anemia (FA) Fancd2(-/-) (129/Sv), Fancg(-/-) (B6), and Fanca(-/-) (129/Sv) mice. MATERIALS AND METHODS: JP4-039 dissolved in 30% 2-hydroxypro …
BACKGROUND/AIM: Radiation mitigator, GS-nitroxide, JP4-039, was evaluated for mitigation of total body irradiation (TBI) in Fanconi anemia ( …
Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin.
Metselaar DS, Meel MH, Benedict B, Waranecki P, Koster J, Kaspers GJL, Hulleman E. Metselaar DS, et al. EBioMedicine. 2019 Dec;50:81-92. doi: 10.1016/j.ebiom.2019.10.062. Epub 2019 Nov 14. EBioMedicine. 2019. PMID: 31735550 Free PMC article.
Since aberrant expression of DNA damage-response associated Fanconi anemia proteins play a central role in the onset and therapy resistance of many cancers, we here investigated if FANCD2 depletion could sensitize pHGG to additional DNA damage. METHODS: We determined the c …
Since aberrant expression of DNA damage-response associated Fanconi anemia proteins play a central role in the onset and therapy resistance …
FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.
Goold R, Flower M, Moss DH, Medway C, Wood-Kaczmar A, Andre R, Farshim P, Bates GP, Holmans P, Jones L, Tabrizi SJ. Goold R, et al. Hum Mol Genet. 2019 Feb 15;28(4):650-661. doi: 10.1093/hmg/ddy375. Hum Mol Genet. 2019. PMID: 30358836 Free PMC article.
Huntington's disease (HD) is an inherited neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) gene. ...Genome-wide association studies have identified a bidirectional signal on chromosome 15, likely underlain by FANCD2- and FANC …
Huntington's disease (HD) is an inherited neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) g …
Systematic Analysis and Validation of the Prognosis, Immunological Role and Biology Function of the Ferroptosis-Related lncRNA GSEC/miRNA-101-3p/CISD1 Axis in Lung Adenocarcinoma.
Jiang X, Yuan Y, Tang L, Wang J, Zhang D, Duan L. Jiang X, et al. Front Mol Biosci. 2022 Mar 7;8:793732. doi: 10.3389/fmolb.2021.793732. eCollection 2021. Front Mol Biosci. 2022. PMID: 35320929 Free PMC article.
Our findings revealed that certain FRGs (CISD1, ATP5MC3, PGD, SLC7A11, ACSL3, and FANCD2) are significantly upregulated in LUAD and that their elevated expression is associated with both advanced tumor stage and unfavorable prognosis. ...
Our findings revealed that certain FRGs (CISD1, ATP5MC3, PGD, SLC7A11, ACSL3, and FANCD2) are significantly upregulated in LUAD and t …
Icariin improves Fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition.
Li Y, Li X, Cole A, McLaughlin S, Du W. Li Y, et al. Cell Cycle. 2018;17(3):367-376. doi: 10.1080/15384101.2018.1426413. Epub 2018 Feb 8. Cell Cycle. 2018. PMID: 29355456 Free PMC article.
Further analysis reveals that ICA upregulates enzyme activity of the chromatin binding protein SIRT6 in Fanca(-)(/)(-) and Fancd2(-)(/)(-) HSCs, both of which have an intrinsic low SIRT6 activity. Furthermore, forced expression of SIRT6 blocks the natural decline of quiesc …
Further analysis reveals that ICA upregulates enzyme activity of the chromatin binding protein SIRT6 in Fanca(-)(/)(-) and Fancd2(-)( …
Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039).
Willis J, Epperly MW, Fisher R, Zhang X, Shields D, Hou W, Wang H, Li S, Wipf P, Parmar K, Guinan E, Steinman J, Greenberger JS. Willis J, et al. Radiat Res. 2018 Jun;189(6):560-578. doi: 10.1667/RR14878.1. Epub 2018 Mar 27. Radiat Res. 2018. PMID: 29584588 Free PMC article.
FA patients commonly display radiosensitivity of epithelial tissues, complicating effective radiotherapy. Fancd2(-/-) mice (C57BL/6J and 129/Sv background) demonstrate epithelial tissue sensitivity to single-fraction or fractionated irradiation to the head and neck and dis …
FA patients commonly display radiosensitivity of epithelial tissues, complicating effective radiotherapy. Fancd2(-/-) mice (C57BL/6J …
Fancf-deficient mice are prone to develop ovarian tumours.
Bakker ST, van de Vrugt HJ, Visser JA, Delzenne-Goette E, van der Wal A, Berns MA, van de Ven M, Oostra AB, de Vries S, Kramer P, Arwert F, van der Valk M, de Winter JP, te Riele H. Bakker ST, et al. J Pathol. 2012 Jan;226(1):28-39. doi: 10.1002/path.2992. Epub 2011 Nov 14. J Pathol. 2012. PMID: 21915857
Fancf-deficient mouse embryonic fibroblasts displayed a phenotype typical for FA cells: they showed an aberrant response to DNA cross-linking agents as manifested by G(2) arrest, chromosomal aberrations, reduced survival, and an inability to monoubiquitinate FANCD2. Fancf …
Fancf-deficient mouse embryonic fibroblasts displayed a phenotype typical for FA cells: they showed an aberrant response to DNA cross-linkin …
27 results